Inter-trial variability in mismatch negativity – new insight into abnormal mismatch negativity in schizophrenia

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Mismatch negativity

New perspectives in cognitive1,2 and clinical3,4 neuroscience have been opened up with the recent discovery of mismatch negativity (MMN),5 an auditory event-related brain potential (ERP) elicited by infrequent deviant sounds occurring in a sequence of repeated tones.1 The MMN appears as a negative displacement on the ERP to deviant sounds relative to that to standard sounds, with a peak latency...

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[Mismatch Negativity (MMN) and schizophrenia: a revision].

The Mismatch Negativity (MMN) is an auditory Event- Related Potential which is generated as an automatic cerebral response to any change in the auditory stimulation that exceeds a limit corresponding to the discrimination threshold. It has been widely and consistently reported that patients with recent and chronic schizophrenia display smaller MMN amplitudes, suggesting that this component may ...

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Mismatch negativity in chronic schizophrenia and first-episode schizophrenia.

BACKGROUND Mismatch negativity (MMN) is an event-related brain potential that is sensitive to stimulus deviation from a repetitive pattern. The MMN is thought primarily to reflect the activity of sensory memory, with, at most, moderate influences of higher-level cognitive processes, such as attention. The MMN is reported to be reduced in patients with chronic schizophrenia. However, it is unkno...

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Abnormal pitch mismatch negativity in individuals with schizotypal personality disorder.

BACKGROUND The goal of the study was to examine mismatch negativity (MMN) in schizotypal personality disorder (SPD) individuals. Abnormal MMN has been a consistent finding in chronic schizophrenia and there also have been reports of reduced duration MMN in first episode schizophrenia patients [Umbricht, D., Krljes, S., Mismatch negativity in schizophrenia: a meta-analysis. Schizophrenia Researc...

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Gray matter deficits, mismatch negativity, and outcomes in schizophrenia.

Reduced mismatch negativity (MMN) in response to auditory change is a well-established finding in schizophrenia and has been shown to be correlated with impaired daily functioning, rather than with hallmark signs and symptoms of the disorder. In this study, we investigated (1) whether the relationship between reduced MMN and impaired daily functioning is mediated by cortical volume loss in temp...

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ژورنال

عنوان ژورنال: Frontiers in Neuroscience

سال: 2010

ISSN: 1662-453X

DOI: 10.3389/conf.fnins.2010.06.00290